The instructions that make us who we are translate into a diverse array of complex and highly regulated processes that occur precisely and on time in every single cell. Mistakes in these processes can lead to disease. Scientists at the Max Perutz Labs study fundamental cellular and developmental processes at a mechanistic level.
Genetic information is encoded in genes, embedded in chromatin, and organized in chromosomes. Its implementation is dynamically regulated at different levels from DNA to RNA. At the Max Perutz Labs, scientists focus on fundamental processes of inheritance, nuclear architecture, genome organization, and RNA biology from bacteria to humans.
Malfunctions in our defense systems account for more than 85% of all human deaths. Max Perutz Labs scientists dissect the molecular mechanisms underlying the regulation of immune tolerance, signaling pathways in sterile and pathogenic inflammation, including cancer, as well as the principal mechanisms of immune surveillance in healthy, autoimmune, and infectious disease settings.
Biological processes are driven by the coordinated interaction of molecules within cells and tissues. The Max Perutz Labs studies how structure is related to function, the dynamics and energetics of the macromolecules that are at the heart of these processes, and the networks in which they operate. We aim to elucidate the mechanisms that shape our normal physiology and rationalize the role of aberrant macromolecules in disease.